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Early studies showed that growth hormone did not directly stimulate the incorporation of sulfate into cartilage, but rather acted through a serum factor, termed sulfation factor, which later became known as somatomedin

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It synthesizes the latest evidence from PubMed/Medline, Web of Science, and Cochrane Library databases up to January 2025, focusing on the immune mechanisms, inflammation, and therapeutic strategies related to CKD-MBD