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The thiol group in proteins can usually be oxidized in the following ways, where GSH is glutathione, GSSG is glutathione disulfide, RSH is a protein containing a thiol group with R being the protein residue

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A total of 4 DEGs associated with glutathione metabolism were identified in P

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Clinical trials show oral glutathione at 500mg doses reduces melanin index when taken consistently for 8-12 weeks