The rate limiting amino acid in de novo synthesis of GSH in metabolic disease appears to be glycine
doi: 10.3390/cells11223632 Summary Keywords cancer, drug resistance, tumor microenvironment (TME), molecular mechanisms, artificial intelligence (AI), precision oncology, drug sensitivity profiling, therapeutic strategies Citation Xu H, Lu J, Wu J, Zhang K, Zhou X, Gao Z, Feng J, Zhuang Z and Zhong X (2025) Integrated molecular and microenvironmental drivers of drug resistance in gastrointestinal cancers: mechanisms, immunotherapy challenges, and precision strategies
These benefits include bypassing the blood-retina barrier for targeted drug delivery, prolonged drug release and reduced systemic side effects
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