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The lysosomal protein and sfGFP delivered to the lysosome are degraded and inactivated

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Surgical thyroidectomy Surgical thyroidectomy is a potentially curative treatment with the disadvantage of requiring general anaesthesia (which may be contraindicated in some patients), and is only suitable for those cases with easily accessible hyperfunctional thyroid tissue ( Figure 2 )

At each post-operative time point of interest, mice were then euthanized with intraperitoneal injection of pentobarbital

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