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Increased microtubule-associated protein light chain 3II (LC3-II) levels or LC3-II/LC3-I ratios are commonly observed in cells exposed to NMDA or other glutamate receptor agonists [127]

In our study, when administered in monotherapy, daily Tadalafil 5 mg was confirmed to be a safe and effective treatment in all types of ED severity, providing a statistic significant amelioration in the mean IIEF-EF score of 6 points in overall population and of 5.7, 6.7, and 4.9 points in mild, moderate, and severe-ED population, respectively (Table 2)

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Although 11 studies (including nearly 6,000 patients) had a history of suicide attempt/depression as exclusion criteria for enrollment, removal of these studies did not affect the overall findings of the meta-analysis