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3 Results 3.1 Descriptive analysis of included studies The analysis of the included studies provides valuable insights into the field's research landscape

The physical functioning score of the RAND-36 was 40 32% pretreatment and 46 19% posttreatment

Limitations of human biomonitoring and objectives HBM relies not only on validated analytical tools, but also on a clear understanding of the relationship between exposure to a toxin and concentration of that toxin (or metabolite) in a biological sample

The Neelakantan 2018 study reported that 5-Amino-1MQ administration to diet-induced obese mice produced reductions in adipose-tissue NNMT enzymatic activity, with concurrent reductions in fat mass and improvements in glucose tolerance [1]

Researchers have shown improvements in healthspan-related measures in mice, but no study has demonstrated lifespan extension in humans, and the evidence remains preliminary even in animal models