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Antioxidant Substrate Availability GLP-1RAs demonstrate anti-inflammatory [80] and antioxidant-associated effects [81] across both preclinical and clinical studies, although findings are not entirely consistent [82]

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The core mechanism involves Gi/o-mediated cAMP inhibition, accompanied by branch signals such as MAPK/ERK, PKC-Ca2 + , and beta-inhibitor-mediated receptorization, which leads to complex tissue-specific cell responses