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Rapamycin's safety in MCI is currently being evaluated in a Phase I trial (NCT04200911), but the translational hurdle determining whether the medication can continue to engage its targets once neurodegeneration reaches a late-stage plateauremains (236, 237)

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Through the addition of a fatty acid side chain, an acidic gamma-Glu group, and lipophilic 2xOEG groups, the molecule can bind more securely to plasma albumin, thereby reducing its glomerular ltration rate4

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