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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-nave patients with type 2 diabetes (SUSTAIN 4): a randomized, open-label, parallel-group, multicentre, multinational, phase 3a trial

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As seen in Fig 7A and C, IRE1a protein levels were decreased by miR-4488 only at late phases of starvation (24 and 48 h), coinciding with the down-regulation of the proinflammatory genes

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