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Nearly all studies originate from one research group, raising concerns about independent replication

and any medical, neurological, or psychiatric disorder that could reasonably be expected to interfere with the assessment of MS symptoms, or with the study assessments including the FDG PET imaging

Necroptosis can also be materialized as a result of activation of the signaling pathways, due to DNA damage, which leads to the release of apoptosis-related factors from the mitochondrial intermembrane space, followed by the activation of the DNA damagerelated enzyme poly(ADP-ribose) polymerase (PARP) [213]

intuition about overall health and symptoms progression guided the decision to advance to the next stage

Suk-Bong Ha, Aaron P