Clifford, S
A recent phase three program showed it improved A1C (a three-month average of blood sugar) more than comparators [the drugs it was tested against] and led to significant weight loss, with side effects mostly in the digestive tract (nausea, vomiting [and] diarrhea), like other GLP-1 drugs. Wegovy pill Orforglipron isnt the only pill-form GLP-1 generating excitement
They describe reta as a "next-gen" GLP-1 drug, saying the injectable they are taking helped them cut fat and get lean without the muscle wasting that many people experience on Ozempic, Wegovy, Mounjaro, or Zepbound
However, while a few clinical studies have reported small changes in thyroid levels in participants with hypothyroidism on who are on thyroid replacement therapy while taking PPIs, a clear connection has not been firmly established
Larger, higher-quality trials focused on B12 alone simply dont show consistent, clinically meaningful fat loss