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This metabolite was discovered to mitigate ectopic lipid deposition in renal tubular cells, indicating the presence of a gut microbiota5-OPkidney axis (potentially mediated by Clostridium5-OPELD), which may serve as a novel intervention target (Steven et al., 2017

J Cell Signal 3:62 Sundar SV, Zhou JX, Magenheimer BS, Reif GA, Wallace DP, Georg GI, Jakkaraj SR, Tash JS, Yu AS, Li X, Calvet JP (2022) The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease

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