glp 1 gip glucagon GLP-1 receptor agonists are increasingly used to treat type 2 diabetes and obesity, and trials have shown reductions in cardiovascular risk and slowing of kidney failure. Adverse events are mostly gastrointestinal What is the pipeline for

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Footnotes Conflicts of interest No potential conflict of interest relevant to this article was reported

Leptin levels fell during weight loss and increased brain activity in areas involved in emotional, cognitive, and sensory control of food intake

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Urgent medical attention is required if any of the following occur: Severe or persistent vomiting or diarrhoea , which can lead to dehydration and electrolyte imbalances Signs of hypoglycaemia (if taking other glucose-lowering medications): confusion, sweating, tremor, rapid heartbeat, or loss of consciousness Symptoms of worsening hyperthyroidism : significant weight loss, severe palpitations, chest pain, shortness of breath, or new-onset atrial fibrillation Symptoms of hypothyroidism : extreme fatigue, cold intolerance, significant weight gain, or depression Severe abdominal pain , particularly if radiating to the back, which could indicate pancreatitis (a rare but serious side effect of GLP-1 receptor agonists) Right upper quadrant pain, fever, or jaundice , which could indicate gallbladder problems Symptoms of diabetic ketoacidosis : abdominal pain, vomiting, rapid breathing, drowsiness, or fruity-smelling breath (particularly if insulin doses have been reduced) Changes in vision or eye symptoms : pain, redness, double vision, or worsening bulging of the eyes Allergic reactions : rash, itching, swelling of the face or throat, or difficulty breathing Routine follow-up with your GP or endocrinologist should occur at least every 36 months, or more frequently if your condition is not yet stable