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These pathways are also temporally regulated by feeding state, with IRS-2 crucial for gluconeogenesis suppression after fasting and IRS-1 supporting lipogenesis in the fed state

Conclusion These results suggest that the SENP2-PPAR pathway plays an important role in leptin-induced FAO in white adipocytes

The specific binding window for each of n = 3 independent experiments was normalized to radioligand binding in the presence of vehicle only (100%) or displacement caused by 10 M THC (0%)

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