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Calcium oxalate (CaOx) crystals can adhere to and aggregate on the renal tubular epithelial cells, causing damage to the tubular epithelial cells and endothelial-mesenchymal transition, ultimately leading to renal fibrosis (204, 205)

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Mice were euthanized and blood was collected by cardiac puncture and processed immediately for simultaneous determination of EtOH and acetaldehyde by headspace gas chromatography/mass spectrometry (HS-GC/MS) analysis