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Key Points Growth hormone (GH) is a potent metabolic hormone that has been touted as a 'fountain of youth' Recombinant human (rh) GH and insulin-like growth factor 1 (IGF-1) are approved therapeutics for patients with GH deficiency or primary IGF-1 deficiency, respectively

showed immunization of mice against Gpnmb resulted in a reduction of Gpnmb-positive cells

Clinical Trial Dosing Ranges Dose Titration Schedules Clinical trials have employed gradual dose escalation to minimize gastrointestinal side effects [9] : Standard Titration Protocol (Example from ONWARDS 1) Rationale: Gradual titration allows tolerance development to gastrointestinal effects (particularly nausea) while building up to therapeutic doses

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Six engineering decisions matter