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Metformin ameliorates diabetic cardiomyopathy by activating the PK2/PKR pathway

Research backing peptides isnt as extensive as wed like (partly because peptides exist in a regulatory gray zone), but what we have is compelling

This includes developing bifunctional molecules (e.g., Fer-1 conjugated to Nec-1, a necroptosis inhibitor) that co-target complementary pathways or epigenetic editing tools (e.g., dCas9-SunTag-KRAB systems) to dynamically suppress the transcription of ferroptosisnecroptosis crosstalk nodes (e.g., RIPK3)

Liu Y, Yan W, Tohme S, Chen M, Fu Y, Tian D, et al

CA Cancer J Clin (2016) 66(2):11532