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Very common side effects (affecting more than 1 in 10 people) include: Nausea often most pronounced when initiating treatment or increasing the dose Diarrhoea may be transient and typically improves with continued use Decreased appetite a therapeutic effect but may lead to inadequate nutrition if extreme Common side effects (affecting up to 1 in 10 people) include: Vomiting can contribute to dehydration if severe or persistent Constipation may occur as part of gastrointestinal effects Abdominal pain or discomfort usually mild and self-limiting Dyspepsia (indigestion) Fatigue may relate to reduced caloric intake or metabolic changes Injection site reactions redness, itching, or swelling at the injection site Hypoglycaemia particularly when Mounjaro is used in combination with insulin or sulfonylureas [1] [19] To minimise gastrointestinal side effects, the SmPC recommends starting at the lowest dose (2.5 mg weekly) and gradually titrating upwards every four weeks

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GLP-1RA is safe for use in children and adolescents over the age of 10 years, and some formulations have been approved for pediatric T2DM or obesity