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A nivel de tejido adiposo, la contribucin del agonismo GIP y GLP-1 reduce la infiltracin de macrfagos M1 y de citoquinas proinflamatorias como leptina, aumenta la adiponectina e incrementa la insulinosensibilidad, mejorando la disfuncin adipocitaria39

Available from: Montejo AL, et al

In patients with type 2 diabetes and established cardiovascular disease, semaglutide has been shown to reduce the risk of major adverse cardiovascular events (MACE) such as heart attack, stroke, or cardiovascular death