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Current evidence does not establish a direct pharmacological mechanism by which semaglutide would alter mood, though indirect factors such as blood glucose changes or gastrointestinal symptoms may influence emotional wellbeing

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What makes therapeutic peptides compelling for longevity science is their specificity: unlike small-molecule drugs, which often bind promiscuously to multiple receptor types, peptides tend to interact with highly selective targets, producing narrower and more predictable biological effects [1]