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Positively charged nanoparticles, for instance, can extend joint residency by interacting with anionic glycosaminoglycans in the cartilage extracellular matrix and hyaluronic acid in the synovial fluid [49]

While NMN increased oxygen consumption and endurance, it is important to note that NMN did not affect the activity of mitochondrial Oxphos complexes or key enzymes of the TCA cycle 256