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Underpinned by genetic and nutritional counseling, the integration of genetic parameters influencing the response to dietary components, type of exercise, different pharmacotherapies and behavioral traits, such as adherence and reward eating, as well as their interactions, will enable further personalization and greater potential for improved pharmacotherapy outcomes in patients with obesity ( Statements Data availability statement The original contributions presented in this study are included in this article/supplementary material, further inquiries can be directed to the corresponding author