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Some of fisetins notable effects in preclinical studies are lifespan extension, the alleviation of cognitive dysfunction and brain inflammation, protection against kidney damage, and increased muscle size and strength

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reported significant reductions in inflammatory markers and oxidative stress among neonates with sepsis who received melatonin as adjunctive therapy, along with a decrease in mortality risk (El-Gendy et al., 2018)

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Both are antioxidants, but vitamin E (at 800 IU daily) has stronger evidence for improving liver histology in selected adults with biopsy-proven NASH, whereas NAC remains investigational