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All findings are supported with extensive citations from academic studies, industry reports, and recent news

During that window, the manufacturer must negotiate formulary placement to generate the revenue needed to justify the original R&D investment, which the Tufts Center for the Study of Drug Development estimated at approximately $2.6 billion per approved drug (2023 update, including cost of capital)

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447 Moreover, these agents promote hemodynamic equilibrium, 18 diminish thrombotic propensity, 448 alleviate endothelial oxidative stress, 449 attenuate inflammatory processes, 450 and foster a favorable balance of the gut microbiota, 451 all of which collectively contribute to the salutary effects of these agents in patients with AS