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Systemic amyloidosis is commonly associated with plasma cell dyscrasias, chronic inflammatory conditions, dialysis, or hereditary disorders, with the GI tract being one of several organs affected by amyloid deposition

Therefore, exploring the combined application of NNMTi with other interventions has become a research hotspot in recent years

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This is the first clinical-grade safety signal in humans

The foundational obesity finding comes from Kraus and colleagues (Nature, 2014), who showed that knocking down NNMT protected mice against diet-induced obesity establishing NNMT as a metabolic target in the first place