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Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

However, combined use requires clinical awareness of potential pharmacodynamic considerations rather than direct pharmacokinetic interactions

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High doses can cause elevated prolactin, cortisol , and lead to side effects like lethargy, numbness, or hormonal imbalance