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It is generally accepted that the production of oxidants has to be strictly regulated, and that the ability of cells and organisms to adequately respond to oxidative stress is one of the main regulators of aging and lifespan [111]

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Edwards et al., 1990) compared to likely cytosolic NADPH concentrations (around 150 M: Igamberdiev and Gardestrm, 2003), this could occur through adjustment of reactant concentrations in the NADP-glutathione equilibrium rather than kinetic limitation of GR activity by NADPH

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