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Starting Semaglutide: What to Expect Your First Week Your first semaglutide injection typically uses a low starter dose designed to minimize side effects while your body adjusts

Decreasing glucagon secretion : This further aids in blood sugar control with GLP-1 agonists

While semaglutide itself is not primarily metabolized by the CYP3A4 enzyme that grapefruit blocks, it's safest to avoid grapefruit juice to prevent indirect interactions with other medications you may be taking

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