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GLP-1 agonists is currently approved as second/third-line therapy for T2DM patients with inadequate glycaemic control (HbA1c 7.0 or 53 mmol/mol) despite lifestyle modifications and first-line antihyperglycaemics (metformin/sulfonylurea/insulin)

Cell lines were generated as indicated and each condition was collected in triplicates of 1,000,000 cells each

Other diabetes medications, particularly insulin or sulfonylureas, may require dose adjustments to prevent hypoglycaemia

It is a rare disorder characterized by insufficient production of cortisol and aldosterone hormones due to the adrenal glands' damage

Further research is needed to elucidate these compensatory mechanisms