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Determining your maintenance calories, setting the calorie deficit and, most critically of all, determining your optimal protein intakes

This can increase swelling in the legs and make varicose veins more uncomfortable

[1] [2] The vitamin's water-soluble nature means that excess amounts are typically excreted through urine rather than accumulating in the body to toxic levels

SGLT2 inhibitors increase urinary glucose and water excretion and can precipitate euglycemic diabetic ketoacidosis, which may present with thirst, nausea, and vomiting even when blood glucose levels are not severely elevated

If you had intolerable side effects on one medication, switching to the other under medical supervision may improve tolerability, since the molecules are different enough to produce different individual responses