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The pioneering 2017 Phase 1b trial of setmelanotide (mentioned above), while providing a critical proof-of-concept for weight loss in a small cohort of heterozygous carriers, was primarily designed as an exploratory study

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Simultaneous measurement of antibodies to Epstein-Barr virus, human herpesvirus 6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue syndrome: is there evidence of activation of a nonspecific polyclonal immune response