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Our findings reveal that tirzepatide attenuates alcohol-induced dopamine signalling, reduces alcohol consumption, and suppresses relapse-like behaviours. Because alcohol, nicotine, and many drugs of abuse hijack the brains reward circuitry, dampening dopamine spikes could help explain why alcohol seemed less compelling to the animals

The analysis of repeated treatment in the ShA study showed a significant effect of LIR treatment on active responding (F1,81 = 8.19, p = 0.005), indicating fewer active nose-pokes in LIR-treated rats

CagriSema also shows competitive results at 22-25%, with FDA approval pending

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