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Activation of Caspase-8 promotes Caspase-3-mediated apoptosis (Newton and Manning, 2016) and the NLRP3/Caspase-1 axis (pyroptosis) (Zhu et al., 2016

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The Asp9 forms a hydrogen bond with Arg370, while Ser8 and Ser11 of Tirzepatide form a network of hydrogen bonds involving the receptor residue Glu288, Arg 289, and Asn290

Figure 1 To elucidate these emerging insights, this review focuses specifically on hypothyroidism, rather than thyroid disorders in general, and synthesizes current knowledge on the mechanistic, clinical, and therapeutic implications of gut microbiota in this context

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