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Higher doses have a stronger effect on gastric emptying and colon motility, leading to more frequent and severe digestive disruptions

They can reduce levels of inflammatory biomarkers, such as C-reactive protein and inflammatory cytokines (eg, tumor necrosis factor-alpha and interleukin-6)

Accordingly, acute administration of liraglutide may attenuate intestinal tight junction gene levels via an LPS- and TLR4-dependent mechanism and promote BT under stress conditions, such as those found in the colitis model

Health Promot J Austr 2009;20:205

Thomas, Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1)