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Inhibitory strategies broadly fall into three categories: those that inhibit inhibition of GH secretion from the pituitary (pre-receptor), those that directly inhibit the GHR, and drugs which inhibit downstream components of GHR signaling pathways (post-receptor)

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Side effects that do not appear when many thousands of patients have used a medication may appear when hundreds of thousands have been treated or when treatment has been used for many years

Verhoeven NM, Roos B, Struys EA, Salomons GS, van der Knaap MS, Cornelis JC

Some people may experience more pronounced effects than what clinical averages suggest