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Professor Sugimoto et al

also synthesized a hetero-trifunctional linker, enabling the simultaneous conjugation of the microtubule inhibitor MMAE and the DNA intercalator PBD dimer onto a single antibody, achieving more efficient killing [140]

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Further analysis of aged mice testes after FOXO4-DRI treatment revealed a reduction in interstitial SA--gal activity, along with decreased levels of senescence-associated proteins p53, p21, and p16