We also studied the consequences of PA treatment on the expression of other well-known ferroptosis-related genes and found that PA induced a decreased expression of two key anti-ferroptotic genes: the gluthatione peroxidase 4 (GPX4) and the ferroptosis suppressor protein 1 (FSP1) and an enhanced expression of two key pro-ferroptotic genes: the arachidonate 15-lipoxygenase (ALOX15) and the acyl-CoA synthetase long chain family member 4 (ACSL4)
In: Ballantyne C, ed
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Eli Lilly, on the other hand, has already launched phase I clinical studies on the long-acting amylin agonist eloralintide in combination with zepbond for obesity (NCT06345066 and NCT06916065), directly testing the feasibility of the triple-target combination
Zhou M, Xie Y, Xu S, Xin J, Wang J, Han T, Ting R, Zhang J, An F