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And so then the next argument was, well, it was sponsored by Novo Nordisk and doesnt cardiovascular risk go down when you lose weight

It activates sirtuins, the longevity-associated proteins that regulate cellular aging, and it powers PARP enzymes, which are responsible for DNA repair

Key takeaways Retatrutide isn't approved yet and isn't expected to launch in the UK until at least mid-2026 In clinical trials, target doses ranged from 0.5mg to 12mg weekly, with the most common being 4mg, 8mg, 9mg and 12mg Different dosing schedules were tested, with most people starting at 2mg and escalating every 4 weeks The 12mg dose produced the most weight loss (up to 28.7% after 68 weeks) Starting at 2mg rather than 4mg helped reduce side effects during escalation First to know Get an email the day retatrutide launches in the UK

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Valdecantos et al