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f , Venn diagram showing the overlap between the SynGO database and the 4042 differentially expressed genes in response to GLP-1MK-801 relative to semaglutide

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(1) By binding to GLP-1 receptors, Semaglutide: Enhances insulin secretion Suppresses glucagon release (which reduces blood sugar levels) Delays gastric emptying Promotes satiety These combined actions have been shown to help regulate blood sugar levels and reduce appetite