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There was also an enhancement in their tolerance to salt stress

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So, the problem doesnt appear to be directly driven by hyperglycemia but possibly by other factors related to oxidative stress and inflammation two major culprits in chronic diseases like diabetes

In similar study setups, riboflavin has also been shown to prevent mitochondrial ROS production and DNA release 47

5.1 Iron chelators and iron modifiers Iron chelators and modifiers effectively inhibit cellular ferroptosis by regulating the expression and activity of iron transporters and storage proteins, including transferrin and its receptor (TfR1), ceruloplasmin, ferroportin, divalent metal transporter 1 (DMT1), and other membrane iron transport proteins (24, 26)