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(Article in Japanese) Mori A, Ohashi N, Hayashi S, et al

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CMNs on the head will increase in size by a factor of 1.7, trunk and extremities 2.8-fold, and lower extremities 3.3-fold

23 The main focus of this approach is to talk with patients who are initiating therapy about expected AEs, nonpharmacologic counseling, presence of any other GI conditions, and individualizing dose titrations

They play a key role in: Allergic reactions Wound healing Immune defense against pathogens Regulating inflammation When activated, mast cells release granules filled with bioactive substances, including: Histamine Tryptase Prostaglandins Leukotrienes Cytokines This process is called degranulation and in normal situations (e.g., in response to an insect sting or parasite), it's protective