When to see a doctor Seek medical evaluation if: Hair loss persists beyond 9 to 12 months after weight stabilization You notice patchy bald spots rather than diffuse thinning Hair loss is accompanied by scalp pain, itching, or redness You have additional symptoms suggesting thyroid or nutritional issues The severity is extreme, with visible scalp showing through Hair loss began before starting tirzepatide or weight loss A dermatologist can perform a pull test, examine the scalp with dermoscopy, and order targeted blood work to distinguish telogen effluvium from other causes
They are deeply rooted in complex, measurable physiological disruptions, including severe mitochondrial dysfunction, rampant oxidative stress, and fundamentally impaired energy metabolism
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A maximal single blood sample (~400 l) was obtained via a facial vein at 0, 2, 6, 10, 20, 30, 60 or 90 min after oral gavage ( n = 610 per time point per group), after which the animals were euthanised
