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While beta blockers should limit sympathetic nervous system activation, these benefits may be outweighed by their negative chronotropic effect, especially since the inability to increase heart rate in response to increased demand is a major player in exercise intolerance in HFpEF [61]

Hunter MS

Finally, novel biomarkers from -omics technologies, including plasma metabolites and circulating microRNAs, are outlined briefly ( Figure 1 )

Clinical prediction models of rheumatoid arthritis and its complications: focus on cardiovascular disease and interstitial lung disease

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