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They are determined largely by underlying heart disease [38] (i.e., positive staircase, wherein elevated eNOS and iNOS activity is seen in cardiac muscle and NO basal release sin large arteries is diminished [38,67,68,69])

Thats certainly the case with MOTS-c, a peptide derived from mitochondrial DNA

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Many growth factors (e.g., bFGF, NGF, BDNF, TABLE 3-3 Biological Role of Neurotrophins in Axonal Guidance and Nerve Regeneration NT-4, TGF-B, GDNF

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