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23,614 However, in vitro studies demonstrate that Nrk1/2 depletion abandons the incorporation of NMN into NAD + synthesis

Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output (Matoba et al., 2023)

These results suggest that IL-6 is necessary for the protective effect of caffeine on NAFLD in mice ( Caffeine has shown inhibitory effects in most of the preclinical studies on the effects of caffeine on NAFLD/non-alcoholic steatohepatitis (NASH) ( However, another researcher investigated the effects of caffeine and green coffee extract (GCE) on hepatic lipids in lean female rats with steatosis (Figure 2) ( via drinking water, diet, and gavage, and the doses vary across studies

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