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The rapid 15-minute half-life of IV glutathione suggests frequent dosing may be necessary to maintain blood levels, yet clinical trials show benefits fade regardless of maintenance frequency

Importantly, these elements form a self-sustaining vicious cycle: declining renal function leads to toxin buildup, which further accelerates CKD progression and its systemic complications

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Numerous saponins obtained from the plant's roots have been demonstrated in various studies to improve glucose tolerance, reduce fasting blood sugar, and have antihyperlipidemic effects