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23), in the child and in the parents it is a sign of a genetic condition (van der Woude syndrome) with high recurrence risk (a parent may have the pits but not the cleft)

Structural changes in the NTD also affect the ability of the ligand to bind to the receptor, which in turn affects receptor activation and drug efficacy (Ma et al., 2020)

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This means that you can use it with confidence, knowing that it won't cause any adverse reactions or irritations