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[3] Gwyer, D., Wragg, N

Symptoms of homocystinuria may be mild, intermediate, or severe, and include ocular disorders, vascular abnormalities, skeletal deformations, and intellectual disabilities

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Interestingly, Pycnogenol intake in osteoarthritis patients reduced gene expression of key catabolic and inflammation markers like MMP-3, MMP-13 and IL-1 by more than 50% within knee cartilage (71)