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In middle-aged rats, ergothioneine supplementation led to: Nearly 100% increase in exercise exhaustion time Nearly doubled running distance Increased muscle mass and vascularization Elevated muscle stem cell populations A 2022 study found that ergothioneine supplementation improved aerobic performance in athletes without impairing muscle recovery signaling [9]

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Inflammation regulation: Both NAD+ and glutathione possess anti-inflammatory properties

Reflux concerns: While not an absolute contraindication, a history of severe GERD or Barretts esophagus requires caution, as LSG may exacerbate symptoms