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4, 5 L-PAM resistance is an multifactorial phenomenon attributed to reduced drug accumulation, reduced apoptosis, enhanced DNA repair and enhanced glutathione (GSH)/gluathione-s-transferases

Inui S, Fukuzato Y, Nakajima T, Yoshikawa K, Itami S (2003) Identification of androgen-inducible TGF-beta1 derived from dermal papilla cells as a key mediator in androgenetic alopecia

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Similarly, men who are exposed to chemicals, pesticides, or solvents at work have been found to experience greater oxidative damage in their sperm, leading to reduced fertility